Fundamental deficits of auditory perception in Wernicke's aphasia.

TitleFundamental deficits of auditory perception in Wernicke's aphasia.
Publication TypeJournal Article
Year of Publication2013
AuthorsRobson, H, Grube, M, Ralph, MALambon, Griffiths, TD, Sage, KE
JournalCortex
Volume49
Issue7
Date Published2013 Jul-Aug
Abstract

OBJECTIVE: This work investigates the nature of the comprehension impairment in Wernicke's aphasia (WA), by examining the relationship between deficits in auditory processing of fundamental, non-verbal acoustic stimuli and auditory comprehension. WA, a condition resulting in severely disrupted auditory comprehension, primarily occurs following a cerebrovascular accident (CVA) to the left temporo-parietal cortex. Whilst damage to posterior superior temporal areas is associated with auditory linguistic comprehension impairments, functional-imaging indicates that these areas may not be specific to speech processing but part of a network for generic auditory analysis.
METHODS: We examined analysis of basic acoustic stimuli in WA participants (n = 10) using auditory stimuli reflective of theories of cortical auditory processing and of speech cues. Auditory spectral, temporal and spectro-temporal analysis was assessed using pure-tone frequency discrimination, frequency modulation (FM) detection and the detection of dynamic modulation (DM) in "moving ripple" stimuli. All tasks used criterion-free, adaptive measures of threshold to ensure reliable results at the individual level.
RESULTS: Participants with WA showed normal frequency discrimination but significant impairments in FM and DM detection, relative to age- and hearing-matched controls at the group level (n = 10). At the individual level, there was considerable variation in performance, and thresholds for both FM and DM detection correlated significantly with auditory comprehension abilities in the WA participants.
CONCLUSION: These results demonstrate the co-occurrence of a deficit in fundamental auditory processing of temporal and spectro-temporal non-verbal stimuli in WA, which may have a causal contribution to the auditory language comprehension impairment. Results are discussed in the context of traditional neuropsychology and current models of cortical auditory processing.

ISSN Number1973-8102
KeywordsAcoustic Stimulation, Aged, Aged, 80 and over, Aphasia, Wernicke, Audiometry, Pure-Tone, Auditory Cortex, Auditory Perception, Cognition Disorders, Comprehension, Female, Functional Laterality, Hearing Tests, Humans, Image Processing, Computer-Assisted, Language Tests, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Pitch Discrimination, Psychomotor Performance, Reproducibility of Results
URLhttp://www.ncbi.nlm.nih.gov/pubmed/23351849?dopt=Abstract
DOI10.1016/j.cortex.2012.11.012
Alternate JournalCortex
PubMed ID23351849
Grant List091593 / / Wellcome Trust / United Kingdom
091681 / / Wellcome Trust / United Kingdom